So I have a 06 350z, I did a pull on the highway and a bad misfire occurred afterwards, it read the p0300 code, random misfire, changed plugs to make sure it wasn’t simple problem like that. Took it to a mechanic to run a diagnostic on what’s exactly causing the misfire, they told me it was my lower intake manifold gasket and injectors # 6 and 4. Payed 70 bucks for the labor, went home ordered 6 new injectors and installed and the misfire was still happening. Does anybody know if Nissan is bad about coil packs and such going bad or anything? Btw my car does have 147,000 miles on it

 

So many things can cause misfires. Did you address the lower plenum gasket while you were handling the injectors? It's not uncommon for coil packs to go out, especially if you have leaking spark plug tube seals. Other causes could be cam sensors or crank sensor. With 150k on the clock it's not uncommon for parts like this to start going out.
-Icer

 

Check the coil packs. I got P0300 because one coil was bad. Like icer5160 said, there are many things can cause misfire. Majority issues are coming from spark plugs, coil packs.
Vacuum leaks can also cause P0300. Make sure no leaks surround the lower-top plenum.

 

i did replace all the gaskets while I had the intake manifold off.

 

I have my coil packs coming in soon. I Just wanted to know if there was any special trick with zs or any kind of part known for failing.

 

Also make sure you don't have any vacuum leaks around the intake manifold. A smoke machine is the best way to achieve this, but there are some poor man tricks you can use to test for vacuum leaks (Scotty Kilmer likes to use cigar smoke as an example). Also make sure you match up all your coil pack plugs with the right wiring harness plug. A lot of people get coil pack plugs mixed up causing misfires.The wiring harness should have black on white numbered labels for cyclinders 1 through 6.
-Icer

 

Or you can use the mechanical stethoscope to check for the vacuum leaks around the manifold. As a matter of fact, I just did that couple weeks ago.
You can get the stethoscope from harbor freight in very affordable price. Listen for hissing sound.

To answer your question "I Just wanted to know if there was any special trick with zs or any kind of part known for failing.":
I would say vacuum leaks. I am not sure for known failing parts, usually caused by wear and tear.

 

Does it sound like a diesel engine? I forgot to plug one of my coils back in once and thats the best way to describe how it sounded.

 

It's probably the coil packs. Let us know if that was the solution so we can all learn.

 

+1 for coil packs.
I mixed up 2 on the wiring harness once and had that exact problem.